検索結果

Search Results for " Phosphodiesterase (PDE) "

ターゲット

129

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T10676	Carbodenafil		PDE
	Carbodenafil is a Sildenafil related compound found in healthy foods. Sildenafil is a PDE5 inhibitor (IC50: 5.22 nM).		PDE
T21965	MBCQ		PDE
	MBCQ is an inhibitor of cGMP-specific phosphodiesterase PDE5.		PDE
T6462	Deltarasin		PDE , Ras
	Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.		PDE , Ras
T2129	Zaprinast		PDE
	Zaprinast is a cGMP-selective phosphodiesterase (PDE) inhibitor and a GPR35 agonist. It has a strong activating effect on rat GPR35 and a certain activating effect on human GPR35. It reduces vascular remodeling through a...		PDE
T6054	GSK256066		PDE
	GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2.		PDE
T12150	N-Methylbenzamide		PDE
	N-Methylbenzamide is a potent phosphodiesterase 10A (PDE10A) inhibitor,with anti-cancer activity.		PDE
T27172	Difamilast		PDE
	Difamilast is an inhibitor of phosphodiesterase IV.		PDE
T7888	Enpp-1-IN-1		PDE
	Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)		PDE
T3631	PF-8380		PDE
	PF-8380 is an effective and orally available autotaxin inhibitor (IC50: 2.8 nM, in isolated enzyme assay; 101 nM, in the human whole blood). It modulates lysophosphatidic acid (LPA) levels in vivo/vitro by directly inhib...		PDE
T4695	CP671305		PDE
	CP671305 is an orally active, potent and selective inhibitor of phosphodiesterase-4-D.		PDE
T12267	NSP-805		PDE
	NSP-805 is a potent and selective guinea pig cardiac phosphodiesterase 3 (PDE3) inhibitor.		PDE
T5106	BRL-50481		PDE
	BRL-50481 is a novel and selective inhibitor of PDE7 with IC50s of 0.15, 12.1, 62 and 490 μM for PDE7A, PDE7B, PDE4 and PDE3, respectively.		PDE
T2646	HA130		PDE
	HA130 is a selective ATX (autotaxin) inhibitor.		PDE
T5496	ML-030		PDE
	ML-030 is a potent and selective inhibitor of PDE4(PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2 with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM, respectively)		PDE
T13448	(R)-(-)-Rolipram	(R)-Rolipram,(-)-Rolipram	DNA-PK , Others
	(R)-(-)-Rolipram ((-)-Rolipram) is an R-enantiomer of Rolipram which is a PDE4 inhibitor.		DNA-PK , Others
T4462	Roflumilast N-oxide		PDE
	Roflumilast N-oxide is an inhibitor of PDE type 4.		PDE
T5411	PDE10-IN-1	SEP-0372814	PDE
	PDE10-IN-1 (SEP-0372814) is used for treating CNS and metabolic disorders.		PDE
T1618	Dipyridamole	Persantin,Dypyridamole,Dipyridamol,NSC-515776,Dipyudamine	PDE
	Dipyridamole (Persantin) is a Platelet Aggregation Inhibitor. The physiologic effect of dipyridamole is by means of Decreased Platelet Aggregation.		PDE
T10410	ATX inhibitor 1		PDE
	ATX inhibitor 1 is a potent ATX inhibitor (IC50: 1.23 nM, FS-3 and 2.18 nM, bis-pNPP).		PDE
T27475	GSK356278	GSK-356278,GSK 356278	PDE
	GSK356278 is an effective and selective inhibitor of phosphodiesterase 4 (PDE4), with pIC50s of 8.6, 8.8, and 8.7 for human PDE4A, PDE4B, and PDE4D, respectively. GSK356278 has anti-inflammatory, anxiolytic, and cognitio...		PDE
T7954	YM976		PDE
	YM976 is an orally active PDE4 inhibitor (IC50:2.2 nM)		PDE
T5474	D159687	D 159687	PDE
	D159687 is a selective PDE4D inhibitor,had a procognitive profile as it improved memory in the novel object recognition test but had no antidepressant or anxiolytic benefit.		PDE
T4041	Ziritaxestat	GLPG1690	PDE
	Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients.		PDE
T7346	Lodenafil	Hydroxyhomosildenafil	PDE
	Lodenafil (Hydroxyhomosildenafil) is a potent PDE5 inhibitor, with treatment of erectile dysfunction (ED)		PDE
T12913	Siguazodan	SKF 94836	PDE
			PDE
T23154	Piclamilast	RPR 73401,RP 73401	PDE
	Piclamilast (RP 73401) is a PDE4 inhibitor.		PDE
T10590	Zatolmilast	BPN14770	Others , PDE
	Zatolmilast (BPN14770) is an allosteric inhibitor of selective phosphodiesterase 4D (PDE4D; IC50s: 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3).		Others , PDE
T6548	Irsogladine	Dicloguamine	PDE , AChR
	Irsogladine (Dicloguamine) is an anti-gastric ulcer agent that facilitates gap-junctional intercellular communication through M1 muscarininc acetylcholine receptor binding.		PDE , AChR
T0160	Anagrelide	Anagrelida,Xagrid,Anagrelidum	PDE
	Anagrelide (Xagrid) is a Platelet-reducing Agent. The mechanism of action of anagrelide is as a Phosphodiesterase 3 Inhibitor. The physiologic effect of anagrelide is by means of Decreased Platelet Production.		PDE
T8515	Osoresnontrine	BI-409306	PDE
	Osoresnontrine is a potent and selective inhibitor of PDE9A (IC50 of 52 nM),and can be used in the research of memory.		PDE
T1096	Milrinone	Win 47203	PDE
	Milrinone (Win 47203) is a Phosphodiesterase 3 Inhibitor. The mechanism of action of milrinone is as a Phosphodiesterase 3 Inhibitor.		PDE
T6147	Nortadalafil	Demethyl Tadalafil	PDE
	Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio.		PDE
T8506	THPP-1		PDE
	THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).		PDE
T16499	Mardepodect	PF-2545920	PDE
	Mardepodect (PF-2545920) is a phosphodiesterase inhibitor selective for the PDE10A subtype with an IC50 of 0.37 nM, >1000-fold selectivity over PDE. It is potentially useful for the treatment of schizophrenia. Phosphodie...		PDE
T21865	BC 11-38		PDE
	BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).		PDE
T7542	Amino Tadalafil		PDE
	Amino tadalafil is a potent phosphodiesterase 5 (PDE5) inhibitor.		PDE
T8919	Homo Sildenafil		PDE
	Homo Sildenafil is an analog of Sildenafil, It acts as a phosphodiesterase inhibitor.		PDE
T11689	ITI-214	ITI214	PDE
	ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = ...		PDE
T1745	Balipodect	TAK063,TAK-063,TAK 063	PDE
	Balipodect (TAK063) is a highly effective and selective PDE10A inhibitor (IC50: 0.30 nM); Its selectivity is >15000-fold over other PDEs.		PDE
T5033	Olprinone	Loprinone	PDE
	Olprinone (Loprinone)(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor.Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output ...		PDE
T9805	BAY 2666605		PDE
	BAY 2666605 is an orally active inhibitor of PDE3A and PDE3B with IC50s of 87 nM and 50 nM, respectively. BAY 2666605 has anticancer effects.		PDE
T5101	BW-A 78U	BW-A78U	PDE
	BW-A 78U is a PDE4 inhibitor (IC50: 3 μM). It is not inhibition on the lipopolysaccharide (LPS)-induced TNF-α release.		PDE
T5956	VP3.15 dihydrobromide		GSK-3 , PDE
	VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE7- glycogen synthase kinase (GSK)3 inhibitor(with IC50s of 1.59 μM , 0.88 μM,respectively.)		GSK-3 , PDE
T7642	Cilostamide	OPC3689	PDE
	Cilostamide (OPC3689) is a selective phosphodiesterase (PDE)3A and PDE3B inhibitor(IC50 values of 27 and 50 nM, respectively)		PDE
T15381	Gisadenafil	UK-369003	PDE
	Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.		PDE
T6649	(S)-(+)-Rolipram	(S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram	Apoptosis , PDE
	(S)-(+)-Rolipram ((+)-Rolipram) inhibits human monocyte cyclic AMP-specific PDE4 with IC50 of 0.75 μM, has anti-inflammatory and anti-depressant activity in the central nervous system, less potent than its R enantiomer.		Apoptosis , PDE
T9816	Arofylline	LAS 31025	PDE
	Arofylline (LAS 31025) is a PDE4 inhibitor and can be used for asthma studies.		PDE
T2137	Ibudilast	AV-411,KC-404,MN-166	PDE
	Ibudilast (MN-166)(KC-404;AV-411;MN-166) is a relatively nonselective phosphodiesterase inhibitor. It is approved for use as an anti-inflammatory in Japan.		PDE
T8659	K-Ras-PDEδ-IN-1		PDE
	K-Ras-PDEδ-IN-1 is a potent inhibitor of competitive K-Ras-PDEδ.It binds to the farnesyl binding pocket of PDEδ(Kd of 8 nM).		PDE
T25376	Ensifentrine	Ensifentrina,Ensifentrinum	PDE
	Ensifentrine (Ensifentrinum) is a PDE3/4 inhibitor, although its affinity for PDE3(IC50: 0.4 nM) is 3,440 times higher than that for PDE4(IC50: 1479 nM), that is under clinical development for the treatment of asthma and...		PDE

Compounds

Synonym: (R)-Rolipram,(-)-Rolipram

Target: DNA-PK, Others

Synonym: Persantin,Dypyridamole,Dipyridamol,NSC-515776,Dipyudamine

Synonym: GSK-356278,GSK 356278

Synonym: Hydroxyhomosildenafil

Synonym: RPR 73401,RP 73401

Target: Others, PDE

Irsogladine

T6548

Synonym: Dicloguamine

Target: PDE, AChR

Anagrelide

T0160

Synonym: Anagrelida,Xagrid,Anagrelidum

Synonym: Demethyl Tadalafil

Synonym: TAK063,TAK-063,TAK 063

VP3.15 dihydrobromide

Synonym: (S)-Rolipram,(+)-Rolipram,S- (+)-Rolipram

Target: Apoptosis, PDE

Synonym: AV-411,KC-404,MN-166

Synonym: Ensifentrina,Ensifentrinum

Target: PDE

カタログ番号	製品名	別名	ターゲット
TN1266	3-O-Methylquercetin		IL Receptor , cAMP , PDE
	3-O-Methylquercetin is a selective and competitive PDE3/PDE4 inhibitor, and inhibits PDE3 than PDE4 with a low K(m) value; it inhibits total cAMP- and cGMP-phosphodiesterase (PDE) of guinea pig trachealis at low concentr...		IL Receptor , cAMP , PDE
T8787	Drotaverine hydrochloride		PDE
	Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor，and is an antispasmodic drug, used to enhance cervical dilation during childbirth. Drotaverine hydrochloride is structurally rela...		PDE
TN1416	Ayanin		IL Receptor , P450 , PARP , PDE
	Ayanin has vasorelaxant activity, it also may have the potential for use in treating allergic asthma.The IC(50) value of Ayanin (quercetin-3,7,4'-O-trimethylether) is 2.2microM for inhibiting interleukin (IL)-4 productio...		IL Receptor , P450 , PARP , PDE
T1681	Aminophylline	Phyllocontin	PDE , Adenosine Receptor
	Aminophylline (Phyllocontin) is a competitive nonselective phosphodiesterase inhibitor giving a bronchodilatory effect.		PDE , Adenosine Receptor
T7027	EURYCOMANONE	Pasakbumin A	Others
	Eurycomanone (Pasakbumin A) is cytotoxic on HepG2 cells by inducing apoptosis through the up-regulation of p53 and Bax, and down-regulation of Bcl-2.Eurycomanone has anti-cancer activity, inhibits A549 lung cancer cell p...		Others
TN2159	Robustine		PDE
	Robustine is a natural product, exhibits inhibitory potency against human phosphodiesterase 5 (hPDE5A) in vitro.		PDE
T0892	Diphylline	Dyphylline,Diprophylline	PDE , Adenosine Receptor
	Diphylline (Diprophylline) is a xanthine derivative. Diphylline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Diphylline probably acts as a competitive inhibitor of phosphodies...		PDE , Adenosine Receptor
T2855	Icariin	Ieariline	PDE , PPAR , Autophagy
	Icariin (Ieariline) is a flavonol glycoside, inhibiting PDE5 and PDE4 activities. Icariin also is a PPARα activator.		PDE , PPAR , Autophagy
T3783	Fraxin	Fraxoside,Fraxetin-8-O-glucoside,Paviin	OAT , transporter , PDE
	Fraxin (Fraxoside) is a glucoside of fraxetin.		OAT , transporter , PDE
T0480	Doxofylline	Doxophylline	PDE , Adenosine Receptor
	Doxofylline (Doxophylline) is a methylxanthine derivative with the presence of a dioxolane group in position 7. As a drug used in the treatment of asthma, doxofylline has shown similar efficacy to theophylline but with s...		PDE , Adenosine Receptor
T1083	Theophylline	Theo-24,1,3-Dimethylxanthine	Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy
	Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3...
T6427	Butein	2’,3,4,4’-tetrahydroxy Chalcone	Apoptosis , EGFR , Others , PDE , Autophagy
	Butein (2’,3,4,4’-tetrahydroxy Chalcone), a plant polyphenol, is isolated from Rhus verniciflua. It can inhibit the activation of protein tyrosine kinase, NF-κB and STAT3, and also can inhibit EGFR.		Apoptosis , EGFR , Others , PDE , Autophagy
T0167	Vinpocetine	RGH-4405,Ethyl apovincaminate	IκB/IKK , NF-κB , Sodium Channel , PDE
	Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).		IκB/IKK , NF-κB , Sodium Channel , PDE
T2205	Acefylline	Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid	TNF , PAD , PKA , HDAC , PDE , Adenosine Receptor
	Acefylline (Theophylline-7-acetic acid), a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in the pharmaceutical preparation Etanautine to help...		TNF , PAD , PKA , HDAC , PDE , Adenosine Receptor
T5S2059	Glaucine		Calcium Channel , Dopamine Receptor , Influenza Virus , Adrenergic Receptor , PDE
	Glaucine has antitussive, antioxidative potential and antiviral activities, it may be an anti-arthritic agent, it can enhance LPS and zymosan-induced IL-10 production. Glaucine can inhibit the migration and invasion of h...
T0070	Pentoxifylline	Oxpentifylline,PTX,BL-191	HIV Protease , PDE , Adenosine Receptor , Autophagy
	Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet ...		HIV Protease , PDE , Adenosine Receptor , Autophagy
T17199	Udenafil		PDE
	Udenafil is an inhibitor of PDE5 .		PDE
TN2217	Sophoflavescenol		Others , Beta-Secretase , BACE , PDE , AChR , AChE
	Sophoflavescenol is a mixed inhibitor of PDE5 with a K(i) value of 0.005 microM. Sophoflavescenol has antioxidant, anti-inflammatory, and apoptotic effects , these effects might contribute to the antitumor activity witho...		Others , Beta-Secretase , BACE , PDE , AChR , AChE
T5940	Proxyphylline	7-(2-Hydroxypropyl)theophylline	PDE , Adenosine Receptor
	Proxyphylline (7-(2-Hydroxypropyl)theophylline) is a dual of adenosine A1/A2a receptor inhibitor and phosphodiesterase (PDE) inhibitor. Proxyphylline acts as a cardiac stimulant, vasodilator and bronchodilator.		PDE , Adenosine Receptor
TN2974	3-O-Methylquercetin tetraacetate		IL Receptor , TNF , PDE
	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.		IL Receptor , TNF , PDE

天然物製品

3-O-Methylquercetin

TN1266

Synonym:

Target: IL Receptor, cAMP, PDE

Drotaverine hydrochloride

Target: IL Receptor, P450, PARP, PDE

Aminophylline

T1681

Synonym: Phyllocontin

Target: PDE, Adenosine Receptor

EURYCOMANONE

T7027

Synonym: Pasakbumin A

Synonym: Dyphylline,Diprophylline

Target: PDE, Adenosine Receptor

Icariin

T2855

Synonym: Ieariline

Target: PDE, PPAR, Autophagy

Fraxin

T3783

Synonym: Fraxoside,Fraxetin-8-O-glucoside,Paviin

Target: OAT, transporter, PDE

Doxofylline

T0480

Synonym: Doxophylline

Target: PDE, Adenosine Receptor

Theophylline

T1083

Synonym: Theo-24,1,3-Dimethylxanthine

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Butein

T6427

Synonym: 2’,3,4,4’-tetrahydroxy Chalcone

Target: Apoptosis, EGFR, Others, PDE, Autophagy

Vinpocetine

T0167

Synonym: RGH-4405,Ethyl apovincaminate

Target: IκB/IKK, NF-κB, Sodium Channel, PDE

Acefylline

T2205

Synonym: Theophylline-7-acetic acid,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid

Target: TNF, PAD, PKA, HDAC, PDE, Adenosine Receptor

Glaucine

T5S2059

Synonym:

Target: Calcium Channel, Dopamine Receptor, Influenza Virus, Adrenergic Receptor, PDE

Pentoxifylline

T0070

Synonym: Oxpentifylline,PTX,BL-191

Target: HIV Protease, PDE, Adenosine Receptor, Autophagy

Target: Others, Beta-Secretase, BACE, PDE, AChR, AChE

Proxyphylline

T5940

Synonym: 7-(2-Hydroxypropyl)theophylline

Target: PDE, Adenosine Receptor

3-O-Methylquercetin tetraacetate

TN2974

Synonym:

Target: IL Receptor, TNF, PDE

Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPY-02081	PDE2A Protein, Human, Recombinant (aa 215-900, His)	Human	Baculovirus-Insect Cells
	cGMP-dependent 3',5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 sub...
TMPY-01819	PDE1B Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B, also known as Cam-PDE 1B and PDE1B, is a cytoplasm protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE1 subfamily. Pho...
TMPY-01922	PDE9A Protein, Human, Recombinant (His & GST)	Human	Baculovirus-Insect Cells
	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, br...
TMPY-01921	PDE9A Protein, Human, Recombinant (His)	Human	E. coli
	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, also known as PDE9A, is a member of the cyclic nucleotide phosphodiesterase family and PDE9 subfamily. PDE9A is expressed in all tissues examined (testis, br...

PDE2A Protein, Human, Recombinant (aa 215-900, His)

TMPY-02081

Species: Human

Expression System: Baculovirus-Insect Cells

PDE1B Protein, Human, Recombinant (His & GST)

TMPY-01819

Species: Human

Expression System: Baculovirus-Insect Cells

PDE9A Protein, Human, Recombinant (His & GST)

TMPY-01922

Species: Human

Expression System: Baculovirus-Insect Cells

PDE9A Protein, Human, Recombinant (His)

TMPY-01921

Species: Human

Expression System: E. coli